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It was derived from epithalamin, a polypeptide complex naturally secreted by the pineal gland in very small quantities

Here two different pharmacological agents known to induce gut permeability (ethanol and AT1002, a Vibrio cholerae zonula occludens toxin hexapeptide) were used to induce transient increase in gut permeability in mice before their exposure to experimental colitis

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Subsequently, Roitt et al.(6) observed that a precipitate formed when an extract of human thyroid gland was added to serum from a patient with Hashimoto's thyroiditis

The authors would like to thank the Roger de Spoelberch Foundation for funding the electron microscopy platform (LCSB/LNS)

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