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To view digital features for this article, go to Introduction Some scientists have proposed that the skin cannot be treated fully from the inside to the outside owing to the anatomy and physiology of dermal structures [1]

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Skin Aging and Photoaging: Examine its potential to reverse markers of aging such as matrix metalloproteinase (MMP) overexpression and reduced dermal thickness in UV-exposed or senescent cell models

Watson et al., 2019

While this results in 100% bioavailability, it comes with significant risks