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Given the binary nature of side effect phenotype definitions, we fitted multi-variable logistic regression models (equivalent to a generalized linear model with a binomial family and logit link function)

Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (Nuclear factor B) signals

PUFAs inhibit the p38MAPK inflammatory pathway, which modulates microglia activity, thus inhibiting cytokine release and neuroinflammation

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This increases blood flow and lowers blood pressure (both markers of improved vascular health)

Breakthrough science or a commercially elegant shortcut