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doi:10.1136/bmjopen-2017-016224

So, what is it exactly

Discovery In the early 1980s, researchers discovered proglucagon, a precursor protein found in the pancreas and intestines

YAP inhibits insulin-like growth factor (IGF) during the IGF pathway activation, which leads to the stabilization and nuclear translocation of -catenin (promoting heart development) (Xin et al., 2011)