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Some people notice reduced appetite, smaller portion size, or fewer cravings

6.1 Osteocalcin as an endocrine regulator of metabolism Osteocalcin is the most extensively studied endocrine peptide derived from bone

Symptoms of mania can include severe insomnia (trouble sleeping), racing thoughts, impulsive or reckless behavior, and extreme levels of happiness, excitement, or activity

Key takeaway: Retatrutide delivers 24.2% weight loss (versus 14.9% for Wegovy and 20.9% for Zepbound) while maintaining a side effect profile thats actually better than Wegovy in several categories

Offer stepwise titration and informed consent that includes potential pro-growth risks

Recommending lower-calorie or less-sweet drink options, such as light beer or dry wine, helps patients make choices that align with their diabetes management goals