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Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction

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Glucagon-like peptide 1 (GLP-1) controls insulin release from the pancreas, which in turn controls glucose homeostasis

Other Potential Effects Acromegaly-like effects from chronic IGF-1 elevation could theoretically include jaw enlargement, soft tissue growth, carpal tunnel syndrome, joint pain, and organ enlargement, though these typically require prolonged excessive elevation