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The evidence base differs significantly between these compounds

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Furthermore it was illustrated that multiple lysosomotropic compounds can redistribute the mannose 6-phosphate receptor from the trans-Golgi network to endosomes and concomitantly increase the secretion of lysosomal enzymes, resulting in a decline of intracellular lysosomal enzyme levels [36], which could further exacerbate the lysosomal dysfunction

However, pulling the acid end of the lipid tail to the opposite leaflet imposed a 7.5 kcal mol 1 free energy barrier due to the Glu-2xOEG linker being pulled past the phosphate headgroups