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In patients with Stanford type A aortic dissection, iron levels and the lipid peroxidation product 4-HNE were increased in the aorta, while key ferroptosis regulatory proteins, including SLC7A11, GPX4, and FSP1 were downregulated

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In addition to PAMPs, the host generates damage-associated molecular patterns (DAMPs) in response to tissue injury, cell death, and other stressors (40)

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Furthermore, the association of active histone codes H3K4Me3 and H3K9Ac was significantly reduced after NRF2 silencing (Fig