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Polyelectrolyte complexes of carboxymethyl chitosan/alginate based drug carrier for targeted and controlled release of dual drug
Medications like semaglutide (Ozempic, Wegovy), a glucagon-like peptide 1 (GLP-1) agonist, and tirzepatide (Mounjaro, Zepbound), a GLP-1 and gastric inhibitory peptide (GIP) receptor agonist, have taken the weight loss world by storm because of their dramatic results
These tags are mainly functional groups that allow biocompatible ligation reactions, such as amide bond formation through activated carboxylates, 337 dialdehyde click reaction, 338 Staudinger ligation, 339 and strain-promoted azide-alkyne cycloaddition (SPAAC)
Specifically, GLP-1 has been shown to stimulate the electrical activity of the hypothalamic proopiomelanocortin neurons in the ARC by enhancing protein kinase A production and by increasing L-type calcium channel expression [38]
Cai J, Yang J, Chen X, Zhang H, Zhu Y, Liu Q, et al
WHO CAN USE THE NATURAL GLP-1 ACTIVATION PROTOCOL BUNDLE
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