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The pathways by which lipid-based formulations alter the pharmacokinetics and bioavailability of associated cargo molecules may occur through physical, chemical, and/or biological mechanisms (Yao et al., 2014)

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Alternatively, in CD8 + T cells, excess glutarate has pleotropic effects on metabolism, altering Lp glu , K glu and also competitively inhibiting 2-OGDDs 9

Clin Neurosci Res 6:261281 Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL (2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases