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The GLP-1 RA journey in PD has been turbulent: early enthusiasm, promising signals, and now sobering late-stage failures

[100] reported a meta-analysis of 33 published and unpublished trials that evaluated the effect of GLP-1 RAs and had information on major adverse cardiovascular events (MACE), mortality, and cardiovascular risk factors

BMC Public Health ;19:1024

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It is known that motor neurons are particularly susceptible to free radicals generated during ischemia, and therefore chronic deficits in neural perfusion may contribute to the development of neuronal damage and disease progression (Kalaria 2002

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