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Gastrointestinal side effects include: Nausea (15-30% of patients depending on dose): Usually mild to moderate and decreasing over time Diarrhea (13-24%): May contribute to dehydration if persistent Vomiting (6-12%): More common at higher doses Constipation (5-17%): Can alternate with diarrhea in some patients Abdominal pain (6-10%): Typically mild and self-limiting Decreased appetite : An intended effect contributing to weight loss Hypoglycemia risk varies depending on concurrent medications

participants reported a 119 percent improvement in well-being after three months and a 72 percent reduction in self-reported cravings after eight months

Examples of water-soluble vitamins include vitamins B and C

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