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So far, data from diabetes use is reassuring, but there is not yet decades of information for weight loss use

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It is expected that tirzepatide will occupy a greater percentage of GIPR than GLP1R (4.1, 4.6, and 6.3 fold, respectively, at 15, 10, and 5 mg) [16]

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By late 2025, it had been updated again, to include effects such as intestinal obstruction and severe constipation including fecal impaction, among several other additions