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J Neurochem 71:388393 Dringen R, Kussmaul L, Hamprecht B (1998b) Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione

doi:10.1210/jc.2018-02385

March 19, 2026

In this model, choline-deficient diet from 3 to 12 months of age disrupted liver and heart normal function, and altered neural networks associated with microtubule stability and postsynaptic membrane regulation in the hippocampus, elevated soluble and insoluble Amyloid- levels, increased Thioflavin S structures, and tau hyperphosphorylation at various pathological epitopes in the hippocampus and cortex (163)

Curr Drug Metab 2012

Older adults face steeper deficits because aging reduces the enzymes responsible for natural glutathione production