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In diabetic populations, erectile dysfunction has been shown to correlate negatively with psychological variables such as depression, anxiety, and perceived stress, indicating that more severe ED is associated with higher levels of psychological distress [81]

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J Ethnopharmacol 151(2):10051018 Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases

Second, nasal administration would rarely be preferred over an oral option from a patient perspective