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Novel strategies under investigation include biomarker-guided therapy using circulating nitric oxide metabolites or endothelin-1 levels, and genetic profiling to identify responders to specific antihypertensive agents 48
Combining compounds multiplies the number of potential side effects at play, and stacking unapproved research chemicals without medical supervision carries meaningfully more risk than using a single compound on its own
This prevents contamination, which can shorten shelf life dramatically
and we dont need to make any changes from the initial dosing to the higher dosing. Dr
Also, FDA stated that supply issues, convenience, and lower cost do not count as clinical need under this pathway