The stained tissue sections were scanned with an AxioScan 7 digital slide scanner (Zeiss) equipped with a 20 objective
While 8% of adults ages 65 and older say they have taken a GLP-1 medication for a chronic condition, just 1% say they have ever taken a GLP-1 drug to lose weight, which may reflect Medicares lack of coverage for prescription drugs used for weight loss
Drug therapy for weight loss has made significant progress
For weight management (Wegovy), the titration reaches 2.4 mg weekly over several steps
Considering these changes in T2DM and the critical role of GLP-1 in glucose homeostasis, strategies for managing T2DM based on this hormone include addressing the differentiation of L-cells, increasing the endogenous production and secretion of GLP-1 through stimulants, extending the half-life of GLP-1 by inhibiting its degrading enzyme and targeting GLP-1R using its agonists
Ozempic doesnt have a generic or biosimilar yet, and due to patent protections, one likely wont be available in the U.S