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The trials were meant to determine if these diabetes drugs would pose significant heart risks

Figure A shows that serum IGF-1 levels were lowest in a moderate protein diet and highest in a Western diet

2023 Jul-Dec;32(11):997-1001

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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Yao H, et al

Mechanisms of Muscle Hypertrophy IGF-1 DES promotes muscle growth through potent activation of IGF-1 receptors on muscle cells, triggering PI3K/Akt/mTOR pathways mediating protein synthesis, increased amino acid and glucose uptake into myocytes, satellite cell activation and proliferation, inhibition of protein degradation (anti-catabolic effects), and enhanced muscle fiber hypertrophy