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It boosts functions when the immune system is underactive and brings it back into balance when it is overactive

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IGF-1 decreased miR-143 expression and increased IGF1R expression in PC-3 and DU145 cells, and made these cell lines more resistant to docetaxel treatment, suggesting that IGF-1 levels are also involved in resistance to treatment in PCa (54)

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And applying heat before stretching or gentle activity can help loosen the joint, while cold therapy may ease inflammation and soreness afterward