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Apart from nonresponse, some DMARDs do cause adverse clinical effects, such as stomatitis, exanthema, diarrhea, anemia, pneumonia, and nephritis, further aggravating the disease condition (1618)

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Therefore, we designed in vitro experiments to verify that Fer-1 rescues the EBV reactivation process and showed by electron microscopy that cellular mitochondria undergo morphological changes typical of ferroptosis, which demonstrates the involvement of ferroptosis during EBV reactivation

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266 In practice, high doses are required to maintain the therapeutic effects, which can lead to corresponding toxicities and side effects