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The effects of separate and combined treatment of male rats with type 2 diabetes with metformin and orthosteric and allosteric agonists of luteinizing hormone receptor on steroidogenesis and spermatogenesis

[55] Thiele, T.E., Roitman, M.F., Bernstein, I.L

Compare week 12 with the week-0 baseline and week 6

This framework thereby bridges molecular mechanisms to clinical disease, demonstrating oxidative stress as a unifying axis in multifactorial pathologies

This albumin binding is the primary determinant of the large apparent volume of distribution and extended half-life