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However, increased oxidative stress (due to UA-induced ROS production from endothelial cells, vascular smooth muscle cells, macrophages and blood-born cells, like monocytes) and pro-inflammatory state induced by the presence of UA within the atherosclerotic plaques promote atherosclerotic plaque propagation and instability

PLoS One 8, e54059

2021 Apr 1;34(2):172-181

Fabisiak A, Murawska N, Fichna J (2016) LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

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Regulation of H 2 S and RSS levels The reactivity of H 2 S and related RSS demands a tight control of their levels, which is ensured both by an intricate regulation of their synthesising enzymes and through an efficient sulphide detoxification pathway located in mitochondria