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Lastly, elevated malondialdehyde (MDA) and decreased glutathione (GSH) levels indicate that chronic exposure to large dosages of TMAO can induce oxidative stress and inflammation in the liver [38]

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A clinical trial demonstrated that EDTA disodium-based infusion reduced recurrent cardiovascular events in type 1 and type 2 diabetic patients with a prior myocardial infarction (131)