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"Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene

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and 5,476,446, each of which is incorporated by reference herein for such disclosure

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To test whether upregulated EPAC activity is required for the survival and growth of transformed melanocytes, we treated the BRAF V600E /PTEN-KD transformed cells with EPAC1/2 inhibitor ESI-09 or EPAC2-selective inhibitor ESI-05 [28, 29]