Wu SH, Yu JH, Liao YT, Liu KH, Chiang ER, Chang MC, Wang JP
Laser Skin Whitening For targeted dark spot reduction
A DSM study from the human nutrition and health department (59) describes hydroxytyrosol as the most powerful anti-inflammatory compound among polyphenols of olive oil, showing effective inhibition in the production of NO and PGE2, decreasing secretion of cytokines (IL-1, IL-1, IL-6, IL-12, TNF-) and chemokines (CXCL10/IP-10, CCL2/MPC-1) and reducing gene expression of iNOS, IL-1, CXCL10/IP-10, MIP-1, matrix metaloproteinase-9, and prostaglandin E2 synthase (PGES)
The tradeoff is that compounded medications are not FDA-approved and carry the caveats discussed in the safety section below
It is best understood as the company's description of its intended product benefit rather than a clinical promise
Rybelsus has additional safety considerations including potential worsening of diabetic retinopathy (particularly with rapid improvement in blood glucose control), risk of dehydration from gastrointestinal effects, increased risk of gallbladder disease, and caution in people with severe gastrointestinal disease or gastroparesis
