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and Europe, the key regulatory authorities reviewing pipeline product trials are the U.S

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The decision was driven by budget constraintsthese medications cost approximately $1,350/month per patient at list price, which became too expensive for the state program to sustain

It has also been reported that glucose transporter 2 (GLUT2) and SGLT2 are upregulated in DM and glucose transport into the cells is significantly increased, suggesting that the kidney contributes to hyperglycemia through gluconeogenesis and enhanced glucose reabsorption

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However, some degree of altered bowel pattern may persist throughout treatment, and symptoms may temporarily worsen with dose increases