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More than 90% of dietary TRP is metabolized via the KP, primarily in the liver [171], generating circulating KYN that readily crosses the BBB, whereas downstream metabolites such as KYNA, QA, and 3-HAA remain largely trapped within the CNS once synthesized [20]

It is a family of polysaccharides ranging from oligomers of a few thousand Daltons to high-molecular-weight chains exceeding 2 million Daltons

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doi:10.1002/nbm.2772, PMID: 22281935 Puri BK, Agour M, Gunatilake KD, Fernando KA, Gurusinghe AI, Treasaden IH (2009) An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome)

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