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published evidence that BPH is caused by failure in the spermatic venous drainage system resulting in increased hydrostatic pressure and local testosterone levels elevated more than 100-fold above serum levels

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5-Amino-1MQ is a substrate-mimetic inhibitor occupying the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)

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