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According to the American Diabetes Association (ADA) Standards of Care, GLP-1 receptor agonists with proven cardiovascular benefit are recommended for many patients with type 2 diabetes who have established cardiovascular disease, with individualized therapy based on patient factors

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In summary, the distinct receptor expression patterns and physiological roles of GLP-1, GIP, and glucagon create complementary mechanisms that, when engaged through mono-, dual-, or triple agonist formulations, address multiple pathogenic pathways in MASLD

1988 Feb;99(2):143-54