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doi: 10.1210/jcem.83.4.4711 127 BelloneJGhizzoniLAimarettiGVoltaCBoghenMFBernasconiSet al

Hyperglucotoxicity and lipotoxicity Persistent hyperglycemia and excess fatty acids in the circulation due to overnutrition and IR have widespread and significant effects on cell function and mass

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152,153 It is worth mentioning that a major activator of TSC1/2 signalling is BDNF, a secreted protein that binds to the receptor tyrosine factor TrKB and is thereby involved in the PI3K/mTOR pathway