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If sleep problems persist , a temporary low-dose melatonin supplement (0.5 to 1 mg, not the 5 to 10 mg doses commonly sold) can help reset circadian rhythm without creating dependence

UV rays can contribute to skin darkening, so a cream with added SPF can help prevent further pigmentation

(4) participant characteristics (age, sex, body weight, body mass index, comorbidities, medication use)

Vitamins and hormones 84, 251278, doi: 10.1016/B978-0-12-381517-0.00009-6 (2010)

Because the medication must be taken on an empty stomach with specific instructions regarding food and fluid intake, conditions that alter gastric pH, motility, or absorption may reduce bioavailability