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Pattern HED extrapolation ceiling Daily Dose ~650 mg/day Tablet Math (50 mg) 13 tablets/day included only to show the gap with vendor doses Frequency n/a Notes Allometric scaling from 100 mg/kg/day mouse dose to 80 kg human

10.1523/JNEUROSCI.3885-07.2007 [DOI] [PMC free article] [PubMed] [Google Scholar] Choi I

Following the initial rounds of therapy, the frequency of sessions may be reduced, with patients returning for periodic treatments based on their ongoing health needs and goals

The provider should schedule regular check-ins (e.g., every 4 weeks initially) to assess tolerance, efficacy, and nutritional status before any dose adjustment

doi: 10.1016/j.ajt.2023.02.004 32 TangGLiSZhangCChenHWangNFengY