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The locus coeruleus is involved in opioid addiction development: in mice, hypothalamic hypocretin innervation increases after morphine administration, correlated with an increase in tyrosine hydroxylase expression (the enzyme that catalyzes the rate limiting step in this synthesis of catecholamines)

[Abstract]2025 Jun 18:111614

Additionally, a co-culture system of MCECs and MPMs revealed that GHK-Cu facilitated MCECs healing, impaired by DSS, by upregulating ZO-1 and Occludin expression