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Studies in older rats have shown that supplementation with high doses of acetyl-L-carnitine and alpha-lipoic acid (an antioxidant) can reduce mitochondrial decay

These benefits may extend to individuals with MASH, however there are currently no retatrutide trials planned in populations with MASLD/MASH

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10.1016/j.cbi.2018.02.019 Chem Biol Interact

Noncoding RNAs With advancements in epigenetics, recent studies have confirmed that endogenous noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play multiple regulatory roles in the formation and deposition of IMF in chickens [75, 76]

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