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Rotating injection sites systematically and avoiding injection immediately before bed (which may cause pressure on the site) can minimise discomfort

For type 2 diabetes , NICE recommends GLP-1 receptor agonists as second- or third-line therapy when metformin and other oral agents have not achieved adequate glycaemic control, or as an alternative to insulin in certain circumstances

Retatrutide at the 12 mg dose produced nausea in 38-43% of Phase 3 trial participants

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