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If you consistently end up a unit or two off, the variance is clinically insignificant

This proportional muscle loss is consistent with weight loss from any cause, including dietary restriction or bariatric surgery, but the rapidity of weight loss with these medications may make this effect more clinically apparent

Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review

Feldman EL, et al

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again

It plays a central role in metabolic regulation by enhancing insulin secretion, suppressing glucagon production, and delaying gastric emptying, thereby controlling postprandial glucose levels