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In addition, calcium influx activates GSK-3 by dephosphorylating it at serine 9 through the calcineurin pathway [38]

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Various studies have shown the beneficial effects of GLP-1 RAs in HF treatment, primarily by enhancing the expression of glucose transporters GLUT1 and GLUT4 via the AMPK/cAMP/PKA pathway, which boosts glucose uptake and improves cardiac function [59]

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