Establishment of diabetic mice Following an overnight fast, mice were injected intraperitoneally with streptozotocin (STZ) at a dose of 150 mg/kg to induce T2DM [27], while control mice received an equivalent volume of sodium citrate buffer
They also concluded: As obesity is a chronic and relapsing condition, prolonged treatment with weight management medications may be required to sustain the health benefits
These benefits extend beyond weight loss, aiding in preventive health management against conditions such as heart disease and diabetes
DPP4 Inhibitors When DPP4 was identified as a therapeutic target, the search began for compounds suitable for clinical use, namely the progressive development of DPP4 inhibitors such as sitagliptin [48] and saxagliptin [49]
doi: 10.3945/ajcn.116.133132 588 UttaraBSinghAVZamboniPMahajanR
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