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Inflammation, smoldering in the damaged intestinal epithelium, activates immune cells that can migrate and cause inflammation to develop in other organs [62, 63]

Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11

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doi:10.1159/000053183 Wilding JPH, Batterham RL, Calanna S, et al