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Mitochondrial Glutathione Reductase Mitochondrial glutathione reductase, while representing a smaller fraction (approximately 10-15%) of total cellular GR activity, fulfills a critical protective function within the mitochondriathe primary site of reactive oxygen species generation in cells

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If the kidneys are already under strain (which is common with age, diabetes, or high blood pressure), this direct load can be too much to handle

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