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61 When administered as 3 or 10 mg/kg intravenously immediately before reperfusion in a canine coronary occlusion-reperfusion model of myocardial infarction, a significant dose-dependent reduction in infarct size was observed

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More importantly, this form of cell death cannot be reversed by caspase inducer [Boc-Asp (OMe)-fluoromethyl ketone] (Dolma et al., 2003)