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The cycling approach alternates treatment periods with break periods, typically following patterns like 3-4 months on followed by 1-2 months off, 6 months on followed by 2-3 months off, or flexible cycling based on skin condition assessment and benefit plateau timing

Targets dull and uneven skin 2

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Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51