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Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen SpeciesStudies in White Blood Cells and in Animal Models

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3 Results In this study, we aimed to determine if three drugs from the SSRI family (sertraline, fluoxetine, and citalopram), commonly used as antidepressants (Figure 1, right panel), can be repurposed as inhibitors of MRP1 and MRP7 transporters (Figure 1, left panel) to overcome MDR in cancer cells

While the clinical trials demonstrated excellent safety in generally healthy obese adults, individual medical histories may reveal concerns not apparent in trial populations