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A phase III HIMALAYA clinical trial has also shown that combination therapy of PD-L1 inhibitor durvalumab and CTLA-4 blocker tremlimumab correlates with improved ORR and OS compared with sorafenib treatment (Abou-Alfa et al., 2022)

A recent study (2024) found that macrophages and neutrophils expressed mincle throughout the transition from AKI to CKD, revealing its impact on the process

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In human and mouse hypertrophic heart models and mice injected with apelin-13, cardiac mitochondrial iron deposition was significantly increased and NCOA4 and sideroflexin 1 (SFXN1) expression was elevated

10.1016/j.cbpc.2023.109663 69 JiangG.ZhangL.WangH.ChenQ.WuX.YanX.et al (2017)