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Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

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Also, single-nucleotide polymorphisms in meningioma-expressed antigen 5 (MGEA5), a human OGA homolog, were associated with T2DM onset in Pima Indians and Mexican Americans [72,73]

10.1046/j.1432-1327.1998.2510382.x Eur J Biochem

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Research suggests that the hormonal and metabolic factors that contribute to weight gain, including elevated ghrelin levels and reduced satiety signaling, tend to reassert themselves after discontinuation