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Melatonins potential to strengthen the BBB appears to involve the upregulation of tight junction proteins, including claudin-5, zonula occludens-1, and occluding [191], which help shield the brain from harmful substances in the bloodstream [192]

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Glutathione inhibits tyrosinase, the enzyme that produces melanin

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Ebrahimpour A., Wang M., Li L., Jegga A.G., Bonnen M.D., Eissa N.T., Raghu G., Jyothula S., Kheradmand F., Hanania N.A., et al