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For each JPY 1 spent on semaglutide 0.5 mg to bring a patient to the target of 1.0% HbA1c reduction and 3.0% weight loss, spending of JPY 2.33 was required with dulaglutide to achieve an equivalent clinical outcome

Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg maintenance dose Can increase to 14 mg after 30 days if needed Rybelsus was finally approved, the first (& only) oral GLP1 agonist

Mechanistic studies in mice show anti-inflammatory and anti-atherogenic effects, including direct attenuation of T-cell-mediated inflammation via gut receptors and indirect modulation of myeloid cell activity through central neuronal pathways

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