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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Vitturi D.A., Sun C.W., Harper V.M., Thrash-Williams B., Cantu-Medellin N., Chacko B.K., Peng N., Dai Y., Wyss J.M., Townes T., et al

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Our CLP model showed chronic Nrf2/HO-1/GPX4 suppression (day 7) linked to GSH depletion, ferroptosis, and irreversible antioxidant collapse (Xie et al., 2020), supporting Nrf2 activators (e.g., sulforaphane) or GSH precursors (e.g., NAC) as interventions (Yusri et al., 2025)