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2 Pathophysiology: molecular and cellular mechanisms of early-stage DR The pathogenesis of early-stage DR involves a cascade of metabolic, inflammatory, and vascular insults triggered by chronic hyperglycemia (Figure 1)

The work supports the broader HGF/c-Met mechanism beyond the hippocampal cognitive context, and the zebrafish protection model has been further studied in subsequent work in mammalian systems

High or low blood sugar levels can lead to restlessness or nocturnal awakenings

PMID: 31743774

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In our study, we utilized fumarylacetoacetate hydrolase (Fah)-/-, Rag2-/-, common cytokine receptor gamma chain knock-out (FRG-KO) humanized mice engrafted with HLA-A2-positive hepatocytes