Inflammation that affects the peripheral nervous system (a network of nerves that runs throughout the head, neck and body), also referred to as neurogenic inflammation, and inflammation that affects the brain and spinal cord, also known as neuroinflammation, are involved in migraines with and without auras and chronic migraines
The several possible routes by which peptides could penetrate the BBB are diffusion, receptor-mediated endocytosis, and carrier-mediated uptake
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References: Raun K , Hansen B , Johansen N , et al
Their interpretation, however, is inherently integrative and iterative: each datasetgenomic variants, biochemical abnormalities, polygenic modulation, and microbiome-derived pathwaysrefines the others as new information becomes available, allowing the multidisciplinary team to recalibrate the emerging clinical model
Liu, X., Wang, X
